期刊
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
卷 21, 期 5, 页码 813-820出版社
SOC BRASILEIRA QUIMICA
DOI: 10.1590/S0103-50532010000500008
关键词
sulfadiazine; pharmaceuticals; electrochemical reduction; square-wave voltammetry; glassy carbon electrode
资金
- CAPES
- CNPq
Sulfadiazine was quantified in two samples of pharmaceutical preparations by square-wave voltammetry. The analytical signal response was obtained by electrochemical reduction instead of oxidation of the sulfa drug at a glassy carbon electrode. The determination was carried out in 0.04 mol L-1 Britton-Robinson pH 6.8 buffer solution. Sulfadiazine reduction was observed at -1.49 V vs. Ag/AgCl in one well-resolved irreversible peak. The analytical curve was obtained in the concentration range of 62.7 to 340 mu mol L-1 (r = 0.9986) with a detection limit of 10.9 mu mol L-1. For one sample analyzed, recovery values were in the range of 94.9 to 101.1%, while for the other sample they were within 96.0 to 104.6%, indicating no matrix interference effects on the analytical results for both sulfadiazine samples. The accuracy of the electroanalytical method was compared to the standard amperometric titration method.
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