期刊
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
卷 21, 期 1, 页码 43-48出版社
SOC BRASILEIRA QUIMICA
DOI: 10.1590/S0103-50532010000100008
关键词
D-glyceraldehyde; heterocyclic compounds; cycloaddition; acetylcholinesterase; Alzheimer's disease
资金
- CONICET [PIP 5011]
- ANPCyT [PICT 13922]
- UBA [X058]
- Fondecyt [1050985]
- Anillo PBCT [ACT-38]
- PBCT [PSD-16]
We report herein the convenient procedures for the syntheses of different heterocyclic compounds from 2,3-O-isopropylidene-D-glyceraldehyde using intramolecular cyclization, 1,3-dipolar cycloaddition or bimolecular coupling reactions. The products were characterized by H-1 and C-13 NMR spectroscopy and elemental analysis. The new heterocycles and their derivatives were evaluated as inhibitors of acetylcholinesterase enzyme.
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