期刊
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
卷 20, 期 1, 页码 176-U222出版社
SOC BRASILEIRA QUIMICA
DOI: 10.1590/S0103-50532009000100026
关键词
antineoplasic; antiparasitic; pterocarpans; naphtoquinones; oxa-Heck reaction; antimalarial; leishmanicide
资金
- PRONEX/FAPERJ
- FAPERJ
- CAPES
- FINEP
- CNPq
Pterocarpanquinones 8a-c, previously synthesized in our laboratory, and an homologous series of derivatives, compounds 9a-c prepared in this work, were evaluated on breast cancer cells (MCF-7) and on the parasites Leishmania amazonensis and Plasmodium falciparum, in culture. Compounds 8a-c were more potent than 9a-c on tumor cells and Leishmania amazonensis. On the other hand, 9a-c showed to be more active on Plasmodium falciparum. All the compounds studied were bioselective, presenting negligible cytotoxicity against fresh murine lymphocytes and human lymphocytes activated by the mitogen phytohemaglutinin (PHA).
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