期刊
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
卷 20, 期 6, 页码 1095-1102出版社
SOC BRASILEIRA QUIMICA
DOI: 10.1590/S0103-50532009000600015
关键词
Annona amazonica; Annonaceae; acanthoic acid; cassythicine; trypanocidal activity
资金
- CAPES
- CNPq,
- FAPESP
- FINEP
- RENOR
The present work reports the isolation of acanthoic acid, a promising pimaradiene-type diterpene with several important biological activities described in the literature, from the stems of Annona amazonica. We found that acanthoic acid has significant trypanocidal activity against the epimastigote forms of Trypanosoma cruzi. This diterpene is the major constituent of the plant, comprising at least 65% of the hexane extract, demonstrating that A. amazonica is a new renewable natural source for this compound. The chemical investigation also resulted in the isolation of the alkaloids liriodenine and cassythicine, and other compounds including terpenes, sterols, and fatty acids. Additionally, the complete and unequivocal H-1 and C-13 NMR chemical shift assignments for cassythicine are provided.
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