期刊
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
卷 20, 期 9, 页码 1653-1658出版社
SOC BRASILEIRA QUIMICA
DOI: 10.1590/S0103-50532009000900013
关键词
fluorescence spectroscopy; resonant light scattering; metallochlorophylls; photodynamic therapy
资金
- FAPESP [06/56701-3, 02/00272-6, 08/50588-6]
- Fundacao Araucaria
- FAPEMIG [EDT 515/05, 102/06, CEX APQ-0571-5.02/08, CEX 652/05]
- CNPq [300391/2005-6, 473920/20077, 470869/2006-2, 479655/2008-1]
- Nanobrax
In this study the role of different metal centers (magnesium, zinc and copper) on the enhancement of the hydrophilic character of metallochlorophylls, was evaluated. The solvatochromism as well as the aggregation process for these compounds in water/ethanol mixtures at different volume ratios were evaluated using Fluorescence, and Resonant Light Scattering (RLS) measurements, aiming to characterize the behavior of these compounds. Independently on the studied metallochlorophyll, the presence of at least 60% of water results in a considerable increase in the fluorescence emission, probably a direct consequence of a lower aggregation of these compounds, which is confirmed by the results from RLS measurements. Additionally, the results suggest that magnesium and zinc chlorophyll should be promising phototherapeutic agents for Photodynamic Therapy.
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