期刊
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
卷 23, 期 3, 页码 400-404出版社
AMER SOC NEPHROLOGY
DOI: 10.1681/ASN.2011080797
关键词
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资金
- National Institutes of Health [1K99DK087922]
- Pennsylvania Department of Health
- National Institutes for Diabetes and Digestive and Kidney Diseases [1R01DK087794-01A1]
- Harvard Stem Cell Institute
MicroRNAs (miRNAs) are a group of small, noncoding RNAs that act as novel regulators of gene expression through the post-transcriptional repression of their target mRNAs. miRNAs have been implicated in diverse biologic processes, and it is estimated that up to half of all transcripts are regulated by miRNAs. Recent studies also demonstrate a critical role for miRNAs in renal development, physiology, and pathophysiology. Understanding the function of miRNAs in the kidney may lead to innovative approaches to renal disease.
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