期刊
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
卷 22, 期 7, 页码 1221-1228出版社
AMER SOC NEPHROLOGY
DOI: 10.1681/ASN.2011010106
关键词
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资金
- Ministry of Science and Technology of China [2011CB965200]
- Chinese Academy of Sciences [KSCX2-YW-R244, KSCX2-YW-G-075 to 18]
- Ministry of Science and Technology China [2007CB948002]
- Ministry of Science and Technology International Technology Cooperation Program [2010DFB30430]
- Bureau of Science and Technology of Guangzhou Municipality, China [2010U1-E00521]
- Austrian Science Fund [S93-06]
- Genome Research Austria GEN-AU [820982]
Forced expression of selected transcription factors can transform somatic cells into embryonic stem cell (ESC)-like cells, termed induced pluripotent stem cells (iPSCs). There is no consensus regarding the preferred tissue from which to harvest donor cells for reprogramming into iPSCs, and some donor cell types may be more prone than others to accumulation of epigenetic imprints and somatic cell mutations. Here, we present a simple, reproducible, noninvasive method for generating human iPSCs from renal tubular cells present in urine. This procedure eliminates many problems associated with other protocols, and the resulting iPSCs display an excellent ability to differentiate. These data suggest that urine may be a preferred source for generating iPSCs.
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