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Resolved: EMT Produces Fibroblasts in the Kidney

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JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
卷 21, 期 8, 页码 1247-1253

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AMER SOC NEPHROLOGY
DOI: 10.1681/ASN.2010060616

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  1. NIDDK NIH HHS [DK73299, DK84077, DK87389, R01DK081576, R03DK081687, K08DK074558] Funding Source: Medline

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Epithelial-mesenchymal transition (EMT) is a mechanism for generating primitive mesenchymal cells during gastrulation or mobile tumor cells during cancer metastasis. For 15 years, EMT has also been viewed as a principal source of fibroblasts in tissue fibrosis. Because several recent studies question its role in fibrogenesis, it seems like a good time for debate.

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