期刊
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
卷 21, 期 3, 页码 398-405出版社
AMER SOC NEPHROLOGY
DOI: 10.1681/ASN.2009080881
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资金
- National Institutes of Health (NIH)/National Heart Lung and Blood Institute [HL094446]
- NIH [DK77532, T32 DK007260-32, DK069381]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL094446] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK069381, R01DK077532, T32DK007260] Funding Source: NIH RePORTER
The increasing numbers of patients with chronic kidney disease combined with no satisfying interventions for preventing or curing the disease emphasize the need to better understand the genes involved in the initiation and progression of complex renal diseases, their interactions with other host genes, and the environment. Linkage and association studies in human, rat, and mouse have been successful in identifying genetic loci for various disease-related phenotypes but have thus far not been very successful identifying underlying genes. The purpose of this review is to summarize the progress in human, rat, and mouse genetic studies to show the concordance between the loci among the different species. The collective utilization of human and nonhuman mammalian datasets and resources can lead to a more rapid narrowing of disease loci and the subsequent identification of candidate genes. In addition, genes identified through these methods can be further characterized and investigated for interactions using animal models, which is not possible in humans.
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