期刊
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
卷 21, 期 11, 页码 1891-1902出版社
AMER SOC NEPHROLOGY
DOI: 10.1681/ASN.2010040368
关键词
-
资金
- National Health & Medical Research Council [511162]
Prenatal ethanol exposure is teratogenic, but the effects of ethanol on kidney development and the health of offspring are incompletely understood Our objective was to investigate the effects of acute ethanol exposure during pregnancy on nephron endowment, mean arterial pressure, and renal function in offspring We administered ethanol or saline by gavage to pregnant Sprague-Dawley rats on embryonic days 13 5 and 145 At 1 month of age, the nephron number was 15% lower and 10% lower in ethanol-exposed males and females, respectively, compared with controls Mean arterial pressure measured in conscious animals via indwelling tail-artery catheter, was 10% higher in both ethanol-exposed males and females compared with controls GFR was 20% higher in ethanol-exposed males but 15% lower in ethanol-exposed females, moreover male. had increased proteinuria compared with controls Furthermore embryonic kidneys cultured in the presence of ethanol for 48 hours had 15% fewer ureteric branch points and tips than kidneys cultured in control media Taken together, these data demonstrate that acute prenatal ethanol exposure reduces the number of nephrons, possibly as a result of inhibited ureteric branching morphogenesis, and that these changes affect adult cardiovascular and renal function
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据