期刊
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
卷 23, 期 6, 页码 1003-1010出版社
SPRINGER
DOI: 10.1007/s13361-012-0377-z
关键词
Deuterium exchange; HDX; H/D exchange; Protein conformation
资金
- NIH [R01-GM086507]
- Waters Corporation
Although the use of hydrogen exchange (HX) mass spectrometry (MS) to study proteins and protein conformation is now over 20 years old, the perception lingers that it still has issues. Is this method, in fact, still in the quicksand with many remaining obstacles to overcome? We do not think so. This critical insight addresses the issues and explores several broad questions including, have the limitations of HX MS been surmounted and has HX MS achieved indispensable status in the pantheon of protein structural analysis tools.
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