A Novel Ion Trap That Enables High Duty Cycle and Wide m/z Range on an Orthogonal Injection TOF Mass Spectrometer

Although TOF analyzers with orthogonal ion injection provide the whole spectrum without scanning, their duty cycle is low compared with scanning analyzers in single ion monitoring mode. Typical duty cycle is in the range of 5% to 30% depending on the instrument geometry and ion m/z value. We present here a novel trapping/releasing setup, which offers the duty cycle near 100% over a wide range. Operation in the mass range from m/z 120 to almost 2000 is demonstrated. Ions are trapped in a short linear ion trap at the end of the collision cell in an axial pseudopotential well created by additional rf (AC) voltage applied to all four rods of the trap with the same amplitude and phase. The pseudopotential created by AC field is mass dependent, and by ramping down the AC voltage, ions can be released from the trap sequentially from high m/z to low, while all ions are gaining the same kinetic energy. Upon entering the TOF accelerator, ions with lower m/z catch up with heavier ions, and the AC ramp parameters can be selected to make all ions meet in the center of the TOF extraction region, resulting in sensitivity gains from 3 to 14 without loss of mass accuracy or resolution. (J Am Soc Mass Spectrom 2009, 20,1342-1348) (C) 2009 American Society for Mass Spectrometry