期刊
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
卷 62, 期 1, 页码 103-110出版社
WILEY
DOI: 10.1111/jgs.12593
关键词
geriatrics; long-term care facility; urinary tract infection; prevention; cranberry
资金
- ZonMw Doelmatigheid, the Dutch Organization for Health Research, the Netherlands [170882501]
- Dutch Organization of Scientific Research (NWO)
ObjectivesTo determine whether cranberry capsules prevent urinary tract infection (UTI) in long-term care facility (LTCF) residents. DesignDouble-blind randomized placebo-controlled multicenter trial. SettingLong-term care facilities (LTCFs). ParticipantsLTCF residents (N=928; 703 women, median age 84). MeasurementsCranberry and placebo capsules were taken twice daily for 12months. Participants were stratified according to UTI risk (risk factors included long-term catheterization, diabetes mellitus, 1 UTI in preceding year). Main outcomes were incidence of UTI according to a clinical definition and a strict definition. ResultsIn participants with high UTI risk at baseline (n=516), the incidence of clinically defined UTI was lower with cranberry capsules than with placebo (62.8 vs 84.8 per 100 person-years at risk, P=.04); the treatment effect was 0.74 (95% confidence interval (CI)=0.57-0.97). For the strict definition, the treatment effect was 1.02 (95% CI=0.68-1.55). No difference in UTI incidence between cranberry and placebo was found in participants with low UTI risk (n=412). ConclusionIn LTCF residents with high UTI risk at baseline, taking cranberry capsules twice daily reduces the incidence of clinically defined UTI, although it does not reduce the incidence of strictly defined UTI. No difference in incidence of UTI was found in residents with low UTI risk.
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