期刊
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
卷 60, 期 10, 页码 1901-1905出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1532-5415.2012.04145.x
关键词
mobility; frailty; disability; mortality; gait
资金
- National Institute of Health (NIH)
- National Institute on Aging (NIA) [RO1 AG025119, PO1 AG03949]
- Paul B. Beeson Award [NIA-K23 AG030857]
- NIH [PO1 AGO3949, RO1 AGO25119, RO1 AGO27734-06A2, RO1 AGO34119, RO1AG12101, K23 AGO30857, K23NS05120901A1, K23 NS47256]
- National Headache Foundation
- Migraine Research Fund
Objectives To examine the validity of the Walking While Talking Test (WWT), a mobility stress test, to predict frailty, disability, and death in high-functioning older adults. Design Prospective cohort study. Setting Community sample. Participants Six hundred thirty-one community-residing adults aged 70 and older participating in the Einstein Aging Study (mean follow-up 32 months). High-functioning status at baseline was defined as absence of disability and dementia and normal walking speeds. Measurements Hazard ratios (HRs) for frailty, disability, and all-cause mortality. Frailty was defined as presence of three out of the following five attributes: weight loss, weakness, exhaustion, low physical activity, and slow gait. The predictive validity of the WWT was also compared with that of the Short Physical Performance Battery (SPPB) for study outcomes. Results Two hundred eighteen participants developed frailty, 88 developed disability, and 49 died. Each 10-cm/s decrease in WWT speed was associated with greater risk of frailty (HR = 1.12, 95% confidence interval (CI) = 1.061.18), disability (HR = 1.13, 95% CI = 1.031.23), and mortality (HR = 1.13, 95% CI = 1.011.27). Most associations remained robust even after accounting for potential confounders and gait speed. Comparisons of HRs and model fit suggest that the WWT may better predict frailty whereas SPPB may better predict disability. Conclusion Mobility stress tests such as the WWT are robust predictors of risk of frailty, disability, and mortality in high-functioning older adults.
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