期刊
PLOS ONE
卷 10, 期 2, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0118534
关键词
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资金
- Deutsche Forschungsgemeinschaft [HE-3260/8-1]
- EU-FP7 Collaborative Project DIABAT [HEALTH -F2-2011-278373]
- Helmholtz Association of German Research Centers [HZ-NG-505]
- German-Israeli-Helmholtz Research School in Cancer Biology
Regulatory T (Treg) cells are critical determinants of both immune responses and metabolic control. Here we show that systemic ablation of Treg cells compromised the adaptation of whole-body energy expenditure to cold exposure, correlating with impairment in thermogenic marker gene expression and massive invasion of pro-inflammatory macrophages in brown adipose tissue (BAT). Indeed, BAT harbored a unique sub-set of Treg cells characterized by a unique gene signature. As these Treg cells respond to BAT activation upon cold exposure, this study defines a BAT-specific Treg sub-set with direct implications for the regulation of energy homeostasis in response to environmental stress.
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