4.6 Article

Brown Adipose Tissue Harbors a Distinct Sub-Population of Regulatory T Cells

期刊

PLOS ONE
卷 10, 期 2, 页码 -

出版社

PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0118534

关键词

-

资金

  1. Deutsche Forschungsgemeinschaft [HE-3260/8-1]
  2. EU-FP7 Collaborative Project DIABAT [HEALTH -F2-2011-278373]
  3. Helmholtz Association of German Research Centers [HZ-NG-505]
  4. German-Israeli-Helmholtz Research School in Cancer Biology

向作者/读者索取更多资源

Regulatory T (Treg) cells are critical determinants of both immune responses and metabolic control. Here we show that systemic ablation of Treg cells compromised the adaptation of whole-body energy expenditure to cold exposure, correlating with impairment in thermogenic marker gene expression and massive invasion of pro-inflammatory macrophages in brown adipose tissue (BAT). Indeed, BAT harbored a unique sub-set of Treg cells characterized by a unique gene signature. As these Treg cells respond to BAT activation upon cold exposure, this study defines a BAT-specific Treg sub-set with direct implications for the regulation of energy homeostasis in response to environmental stress.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据