期刊
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
卷 60, 期 1, 页码 118-123出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1532-5415.2011.03768.x
关键词
dementia; lifestyle; risk
资金
- National Institute on Aging [N01-AG-4-2149, 1-R01-AG17155-01A1]
- National Heart, Lung, and Blood Institute [N01-HC-05102]
- Office of Research and Development, Medical Research Service, Department of Veterans Affairs
OBJECTIVES: To determine whether adhering to a healthy lifestyle in midlife may reduce the risk of dementia. DESIGN: Case-control study nested in a prospective cohort. SETTING: The Honolulu-Asia Aging Study, Oahu, Hawaii. PARTICIPANTS: Three thousand four hundred sixty-eight Japanese-American men (mean age 52 in 1965-1968) examined for dementia 25 years later. MEASUREMENTS: Men at low risk were defined as those with the following midlife characteristics: nonsmoking, body mass index (BMI) less than 25.0 kg/m(2), physically active, and having a healthy diet (based on alcohol, dairy, meat, fish, fruits, vegetables, cereals, and ratio of monounsaturated to saturated fat). Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for developing overall dementia, Alzheimer's disease (AD), and vascular dementia (VaD), adjusting for potential confounders. RESULTS: Dementia was diagnosed in 6.4% of men (52.5% with AD, 35.0% with VaD). Examining the risk factors individually, BMI was most strongly associated with greater risk of overall dementia (OR = 1.87, 95% CI = 1.26-2.77; BMI > 25.0 vs <22.6 kg/m(2)). All of the individual risk factors except diet score were significantly associated with VaD, whereas none were significantly associated with AD alone. Men with all four low-risk characteristics (7.2% of the cohort) had the lowest OR for overall dementia (OR = 0.36, 95% CI = 0.15-0.84). There were no significant associations between the combined low-risk characteristics and the risk of AD alone. CONCLUSION: Among Japanese-American men, having a healthy lifestyle in midlife is associated with a lower risk of dementia in late life. J Am Geriatr Soc 60:118-123, 2012.
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