期刊
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
卷 139, 期 2, 页码 163-169出版社
AMER DENTAL ASSOC
DOI: 10.14219/jada.archive.2008.0132
关键词
ovarian cancer; DNA; hypodontia; genetics; tooth
资金
- NCRR NIH HHS [M01 RR 02602] Funding Source: Medline
Background. Genetic mutations that result in F hypodontia also may be associated with abnormalities in other parts of the body. The authors conducted a study to establish the prevalence rates of hypodontia among subjects with epithelial ovarian cancer (EOC) and control subjects to explore possible genetic associations between these two phenotypes. Methods. The authors recruited 50 subjects with EOC and 100 control subjects who did not have EOC. The authors performed a dental examination on each subject to detect hypodontia, and they reviewed pertinent radiographs and dental histories. They also recorded any family history of cancer and hypodontia. Results: The prevalence of hypodontia was 20 percent for EOC subjects and 3 percent for control subjects. The difference between these two hypodontia rates was significant. This difference implied that women with EOC are 8.1 times more likely to have hypodontia than are women without EOC. The severity of hypodontia was similar between the two groups, with one to two teeth being affected. Maxillary lateral incisors followed by second premolars were the most frequently affected teeth. Conclusion. The preliminary data suggest a statistical association between hypodontia of the permanent dentition and EOC. Clinical Implications. Genetic analysis of the genes of interest is necessary to explore similarities between hypodontia and EOC further: An association could allow hypodontia to serve as a potential risk marker for EOC.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据