期刊
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
卷 31, 期 1, 页码 14-23出版社
AMER COLLEGE NUTRITION
DOI: 10.1080/07315724.2012.10720004
关键词
nonalcoholic and alcoholic liver disease; microflora; probiotics
资金
- National Institutes of Health [P01 AA017103, R01 AA0015970, R01 AA018016, R01 DK071765, R37 AA010762, R01 AA018869, P30 AA019360, RC2AA019385]
- Department of Veterans Affairs
The concept that interactions between the gut, the liver, and the immune system play an important role in liver diseases is an old concept that has recently seen a resurgence in interest. Altered intestinal bacterial flora and gut-associated endotoxemia are increasingly recognized as critical components in both nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). Probiotics have been proposed in the treatment and prevention of many conditions, including the liver diseases. Probiotics are live microorganisms that, when consumed in adequate amounts, confer a health benefit to the host. There are many mechanisms by which probiotics enhance intestinal health and influence the gut-liver axis, including modulation of the intestinal microflora, modification of intestinal barrier function, and immunomodulation. The present review summarizes the recent studies highlighting the role of the intestinal microflora in the development of NAFLD and ALD and the potential efficacy of probiotics as a therapeutic strategy for liver diseases.
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