期刊
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
卷 27, 期 2, 页码 267-273出版社
AMER COLLEGE NUTRITION
DOI: 10.1080/07315724.2008.10719699
关键词
lycopene; DNA damage; oxidative stress; lymphocytes; lipid peroxidation; healthy subjects
资金
- NIH [K24AT00596]
- Roche/DSM Nutritional Products, Inc. Parsippany, NJ
Objective: While tomato product supplementation, containing antioxidant carotenoids, including lycopene, decreases oxidative stress, the role of purified lycopene as an antioxidant remains unclear. Thus, we tested the effects of different doses of purified lycopene supplementation oil biomarkers of oxidative stress in healthy volunteers. Methods: This was a double-blind, randomized, placebo-controlled trial, examining the effects of 8-week Supplementation of purified lycopene, on plasma lycopene levels, biomarkers of lipid peroxidation (LDL oxidizability, malondialdehyde & hydroxynonenals, (MDA & HNE), urinary F-2-isoprostanes). and markets of DNA damage in urine and lymphocytes. Healthy adults (n = 77, age >= 40 years), consumed a lycopene-restricted diet for 2 weeks, and were then randomized to receive 0. 6.5, 15, or 30 mg lycopene/day for 8 weeks, white on the lycopene-restricted diet. Blood and urine samples were collected at the beginning and end of Week 2 of lycopene-restricted diet, and at end of Week 10 of the study. Results: Independent of the dose, plasma lycopene levels significantly increased in all lycopene supplemented groups versus placebo (p < 0.05). ANOVA revealed a significant decrease in DNA damage by the comet assay (p = 0.007) and a significant decrease in urinary 8-hydroxy deoxoguanosine (8-OHdG) at 8 weeks versus baseline (p = 0.0002), with 30 mg lycopene/day. No significant inter- or intra-group differences were noted for glucose. lipid profile. or other biomarkers of lipid peroxidation at any dose/time point. Conclusions: Thus. purified lycopene was bioavailable and was shown to decrease DNA oxidative damage and urinary 8-OHdG at the high dose.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据