期刊
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
卷 63, 期 24, 页码 2659-2673出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2014.02.545
关键词
bare-metal stents; drug-coated balloons; drug-eluting stents; in-stent restenosis; intravascular ultrasound; neoatherosclerosis; optical coherence tomography
资金
- B. Braun
- Biotronik
Management of patients with in-stent restenosis (ISR) remains an important clinical problem. Although drug-eluting stents (DES) have drastically reduced the incidence of ISR, treatment of DES-ISR is particularly challenging. ISR mainly results from aggressive neointimal proliferation, but recent data also suggest that neoatherosclerosis may play an important pathophysiological role. Intracoronary imaging provides unique insights to unravel the underlying substrate of ISR and may be used to guide repeated interventions. In this paper, we systematically reviewed clinical trial data with currently available therapeutic modalities, including DES and drug-coated balloons, in patients presenting with ISR within bare-metal stents or DES. (c) 2014 by the American College of Cardiology Foundation
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