期刊
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
卷 64, 期 12, 页码 1257-1266出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2014.03.062
关键词
aging; diastolic function; distensibility; exercise training; hemodynamics; ventricular compliance
资金
- National Institutes of Health [R01 AG17479]
BACKGROUND Sedentary aging has deleterious effects on the cardiovascular system, including decreased left ventricular compliance and distensibility (LVCD). Conversely, Masters level athletes, who train intensively throughout adulthood, retain youthful LVCD. OBJECTIVES The purpose of this study was to test the hypothesis that preservation of LVCD may be possible with moderate lifelong exercise training. METHODS Healthy seniors (n = 102) were recruited from predefined populations, screened for lifelong patterns of exercise training, and stratified into 4 groups: sedentary (<2 sessions/week); casual (2 to 3 sessions/week); committed (4 to 5 sessions/week); and competitive Masters level athletes (6 to 7 sessions/week). Right heart catheterization and echocardiography were performed while preload was manipulated using lower body negative pressure and rapid saline infusion to define LV pressure-volume relationships and Frank-Starling curves. RESULTS Peak oxygen uptake and LV mass increased with escalating doses of lifelong exercise, with little change in systolic function. At baseline, LV distensibility was greater in committed (21%) and competitive (36%) exercisers than in sedentary subjects. Group LV stiffness constants (sedentary: 0.062 +/- 0.039; casual: 0.079 +/- 0.052; committed: 0.055 +/- 0.033; and competitive: 0.035 +/- 0.033) revealed: 1) increased stiffness in sedentary subjects compared to competitive athletes, whereas lifelong casual exercise had no effect; and 2) greater compliance in committed exercisers than in sedentary or casual exercisers. CONCLUSIONS Low doses of casual, lifelong exercise do not prevent the decreased compliance and distensibility observed with healthy, sedentary aging. In contrast, 4 to 5 exercise sessions/week throughout adulthood prevent most of these age-related changes. As LV stiffening has been implicated in the pathophysiology of many cardiovascular conditions affecting the elderly, this dose of exercise training may have important implications for prevention of cardiovascular disease. (C) 2014 by the American College of Cardiology Foundation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据