期刊
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
卷 61, 期 14, 页码 1471-1481出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2012.11.068
关键词
bare-metal stent(s); drug-eluting stent(s); endothelial dysfunction; nitric oxide synthase; percutaneous coronary intervention; reactive oxygen species; superoxide
资金
- Dutch Heart foundation
- Dutch Government (NWO-Vidi/Aspasia)
- Executive Board of the University of Maastricht
Oxidative stress greatly influences the pathogenesis of various cardiovascular disorders. Coronary interventions, including balloon angioplasty and coronary stent implantation, are associated with increased vascular levels of reactive oxygen species in conjunction with altered endothelial cell and smooth muscle cell function. These alterations potentially lead to restenosis, thrombosis, or endothelial dysfunction in the treated artery. Therefore, the understanding of the pathophysiological role of reactive oxygen species (ROS) generated during or after coronary interventions, or both, is essential to improve the success rate of these procedures. Superoxide O-2(center dot-) anions, whether derived from uncoupled endothelial nitric oxide synthase, nicotinamide adenine dinucleotide phosphate oxidase, xanthine oxidase, or mitochondria, are among the most harmful ROS. O-2(center dot-) can scavenge nitric oxide, modify proteins and nucleotides, and induce proinflammatory signaling, which may lead to greater ROS production. Current innovations in stent technologies, including biodegradable stents, nitric oxide donor-coated stents, and a new generation of drug-eluting stents, therefore address persistent oxidative stress and reduced nitric oxide bioavailability after percutaneous coronary interventions. This review discusses the molecular mechanisms of ROS generation after coronary interventions, the related pathological events-including restenosis, endothelial dysfunction, and stent thrombosis-and possible therapeutic ways forward. (J Am Coll Cardiol 2013;61:1471-81) (C) 2013 by the American College of Cardiology Foundation
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