期刊
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
卷 62, 期 1, 页码 44-50出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2013.03.059
关键词
atrial fibrillation; catheter ablation; pulmonary vein isolation; unexcitability
资金
- St. Jude Medical, Inc.
- Boston Scientific
- Medtronic
- Mediasphere Medical
Objectives This study was conducted to determine if an additional procedural endpoint of unexcitability (UE) to pacing along the ablation line reduces recurrence of atrial fibrillation (AF) or atrial tachycardia (AT) after radiofrequency catheter ablation. Background AF/AT recurrence is common after pulmonary vein isolation (PVI). Methods We included 102 patients from 2 centers (age 63 +/- 10 years; 33 women; left atrium 38 +/- 7 mm; left ventricular ejection fraction 61 +/- 6%) with symptomatic paroxysmal AF. A 3-dimensional mapping system and circumferential mapping catheter were used in all patients for PVI. In group 1 (n = 50), the procedural endpoint was bidirectional block across the ablation line. In group 2 (n = 52), additional UE to bipolar pacing at an output of 10 mA and 2-ms pulse width was required. The primary endpoint was freedom from any AF/AT (>30 s) after discontinuation of antiarrhythmic drugs. Results Procedural endpoints were successfully achieved in all patients. Procedure duration was significantly longer in group 2 (185 +/- 58 min vs. 139 +/- 57 min; p < 0.001); however, fluoroscopy times were not different (23 +/- 9 min vs. 23 +/- 9 min; p = 0.49). After a follow-up of 12 months in all patients, 26 patients (52%) in group 1 versus 43 (82.7%) in group 2 were free from any AF/AT (p = 0.001) after a single procedure. No major complications occurred. Conclusions The use of pacing to ensure UE along the PVI line markedly improved near-term single-procedure success, compared with demonstration of bidirectional block alone. This additional endpoint significantly improved patient outcomes after PVI. (Unexcitability Along the Ablation as an Endpoint for Atrial Fibrillation Ablation; NCT01724437) (C) 2013 by the American College of Cardiology Foundation
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