期刊
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
卷 60, 期 17, 页码 1631-1639出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2012.05.056
关键词
carotid atherosclerosis; diabetes mellitus; metabolic syndrome; obesity; pediatrics
资金
- National Institute of Child Health and Human Development [HD-061437, HD-062783]
- National Institute on Aging [AG-16592]
- Academy of Finland [117797, 126925, 121584]
- Social Insurance Institution of Finland
- Turku University Foundation, Special Federal Grants for the Turku, Tampere
- Kuopio University Central Hospital
- Juho Vainio Foundation
- Finnish Foundation of Cardiovascular Research
- Finnish Cultural Foundation
- Orion Farmos Research Foundation
- Finnish Foundation for Cardiovascular Research
- National Health and Medical Research Council Early Career Fellowship (Public Health Fellowship) [APP1037559]
- Emil Aaltonen Foundation
Objectives The aim of this study was to examine the effect of resolution from metabolic syndrome (MetS) between youth and adulthood on carotid artery intima-media thickness (IMT) and type 2 diabetes mellitus (T2DM). Background Published findings demonstrate that youth with MetS are at increased risk of cardio-metabolic outcomes in adulthood. It is not known whether this risk is attenuated in those who resolve their MetS status. Methods Participants (n = 1,757) from 2 prospective cohort studies were examined as youth (when 9 to 18 years of age) and re-examined 14 to 27 years later. The presence of any 3 components (low high-density lipoprotein cholesterol, high triglycerides, high glucose, high blood pressure, or high body mass index) previously shown to predict adult outcomes defined youth MetS; the harmonized MetS criteria defined adulthood MetS. Participants were classified according to their MetS status at baseline and follow-up and examined for risk of high IMT and T2DM. Results Those with MetS in youth and adulthood were at 3.4 times the risk (95% confidence interval: 2.4 to 4.9) of high IMT and 12.2 times the risk (95% confidence interval: 6.3 to 23.9) of T2DM in adulthood compared with those that did not have MetS at either time-point, whereas those that had resolved their youth MetS status by adulthood showed similar risk to those that did not have MetS at either time-point (p > 0.20 for all comparisons). Conclusions Although youth with MetS are at increased risk of adult high IMT and T2DM, these data indicate that the resolution of youth MetS by adulthood can go some way to normalize this risk to levels seen in those who have never had MetS. (J Am Coll Cardiol 2012;60:1631-9) (c) 2012 by the American College of Cardiology Foundation
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