期刊
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
卷 57, 期 17, 页码 1745-1751出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2010.11.045
关键词
atrial fibrillation; magnetic resonance imaging; obesity; pericardial fat
资金
- Rhodes Trust
- National Heart Foundation of Australia (NHFA)
- University of Adelaide
- Kidney Health Australia Biomedical Research Scholarship
- Bard Electrophysiology
- Biosense Webster
- Medtronic
- St. Jude Medical
- Merck Sharp Dohme
- Sanofi-Aventis
Objectives The aim of this study was to characterize the relationship between pericardial fat and atrial fibrillation (AF). Background Obesity is an important risk factor for AF. Pericardial fat has been hypothesized to exert local pathogenic effects on nearby cardiac structures above and beyond that of systemic adiposity. Methods One hundred ten patients undergoing first-time AF ablation and 20 reference patients without AF underwent cardiac magnetic resonance imaging for the quantification of periatrial, periventricular, and total pericardial fat volumes using a previously validated technique. Together with body mass index and body surface area, these were examined in relation to the presence of AF, the severity of AF, left atrial volume, and long-term AF recurrence after ablation. Results Pericardial fat volumes were significantly associated with the presence of AF, AF chronicity, and AF symptom burden (all p values <0.05). Pericardial fat depots were also predictive of long-term AF recurrence after ablation (p = 0.035). Finally, pericardial fat depots were also associated with left atrial volume (total pericardial fat: r = 0.46, p < 0.001). Importantly, these associations persisted after multivariate adjustment and additional adjustment for body weight. In contrast, however, systemic measures of adiposity, such as body mass index and body surface area, were not associated with these outcomes in multivariate-adjusted models. Conclusions Pericardial fat is associated with the presence of AF, the severity of AF, left atrial volumes, and poorer outcomes after AF ablation. These associations are both independent of and stronger than more systemic measures of adiposity. These findings are consistent with the hypothesis of a local pathogenic effect of pericardial fat on the arrhythmogenic substrate supporting AF. (J Am Coll Cardiol 2011;57:1745-51) (C) 2011 by the American College of Cardiology Foundation
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