期刊
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
卷 57, 期 16, 页码 1641-1649出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2011.01.015
关键词
cardiomyopathy; genetic counseling; genetic testing; genetics
资金
- NIH [RO1-HL58626]
A great deal of progress has recently been made in the discovery and understanding of the genetics of familial dilated cardiomyopathy (FDC). A consensus has emerged that with a new diagnosis of idiopathic dilated cardiomyopathy (IDC), the clinical screening of first-degree family members will reveal FDC in at least 20% to 35% of those family members. Point mutations in 31 autosomal and 2 X-linked genes representing diverse gene ontogeny have been implicated in causing FDC but account for only 30% to 35% of genetic causes. Next-generation sequencing methods have dramatically decreased sequencing costs, making clinical genetic testing feasible for extensive panels of dilated cardiomyopathy genes. Next-generation sequencing also provides opportunities to discover additional genetic causes of FDC and IDC. Guidelines for evaluation and testing of FDC and IDC are now available, and when combined with FDC genetic testing and counseling, will bring FDC/IDC genetics to the forefront of cardiovascular genetic medicine. (J Am Coll Cardiol 2011;57:1641-9) (C) 2011 by the American College of Cardiology Foundation
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