期刊
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
卷 56, 期 14, 页码 1149-1157出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2010.03.085
关键词
congenital heart disease; epidemiology; mortality; population
资金
- Alliance for Quebec Interinstitutional Research (ACQUIRE)
- Fonds de la Recherche en Sante du Quebec
- Canada Research Chair, Electrophysiology and Adult Congenital Heart Disease, University of Montreal
- Canadian Institutes of Health Research
- James McGill Research Chair
- Natural Sciences and Engineering Council of Canada
- Heart and Stroke Foundation of Canada
Objectives This study sought to characterize temporal trends in all-cause mortality in patients with congenital heart disease (CHD). Background Historically, most deaths in patients with CHD occurred in early childhood. Notable advances have since been achieved that may impact on mortality trends. Methods We conducted a population-based cohort study of patients with CHD in Quebec, Canada, from July 1987 to June 2005. A total of 8,561 deaths occurred in 71,686 patients with CHD followed for 982,363 patient-years. Results The proportion of infant and childhood deaths markedly declined from 1987 to 2005, with a reduction in mortality that exceeded that of the general population. Distribution of age at death transitioned from a bimodal to uni-modal, albeit skewed, pattern, more closely approximating the general population. Overall, mortality decreased by 31% (mortality rate ratio: 0.69, 95% confidence interval [CI]: 0.61 to 0.79) in the last (2002 to 2005) relative to the first (1987 to 1990) period of observation. Mortality rates decreased in all age groups below 65 years, with the largest reduction in infants (mortality rate ratio: 0.23, 95% CI: 0.12 to 0.47). In adults 18 to 64 years, the mortality reduction (mortality rate ratio: 0.84, 95% CI: 0.73 to 0.97) paralleled the general population. Gains in survival were mostly driven by reduced mortality in severe forms of CHD, particularly in children (mortality rate ratio: 0.33, 95% CI: 0.19 to 0.60), and were consistent across most subtypes. Conclusions Deaths in CHD have shifted away from infants and towards adults, with a steady increase in age at death and decreasing mortality. (J Am Coll Cardiol 2010; 56: 1149-57) (C) 2010 by the American College of Cardiology Foundation
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