期刊
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
卷 56, 期 22, 页码 1803-1808出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2010.04.065
关键词
air pollution; epidemiology; intima-media thickness; particulate matter; risk factors; subclinical atherosclerosis; traffic
资金
- Heinz Nixdorf Foundation
- German Ministry of Education and Science
- Imatron, Inc., South San Francisco, California
- German Research Council (DFG) [SI236/10-1, SI236/9-1]
- VW Foundation
- Sarstedt AG and Company
Objectives The aim of this study was to investigate the association of long-term residential exposure to fine particles with carotid intima-media thickness (CIMT). Background Experimental and epidemiological evidence suggest that long-term exposure to air pollution might have a causal role in atherogenesis, but epidemiological findings are still inconsistent. We investigate whether urban particulate matter (PM) air pollution is associated with CIMT, a marker of subclinical atherosclerosis. Methods We used baseline data (2000 to 2003) from the HNR (Heinz Nixdorf Recall) study, a population-based cohort of 4,814 participants, 45 to 75 years of age. We assessed residential long-term exposure to PM with a chemistry transport model and measured distance to high traffic. Multiple linear regression was used to estimate associations of air pollutants and traffic with CIMT, adjusting for each other, city of residence, age, sex, diabetes, and lifestyle variables. Results Median CIMT of the 3,380 analyzed participants was 0.66 mm (interquartile range 0.16 mm). An interdecile range increase in PM2.5 (4.2 mu g/m(3)), PM10 (6.7 mu g/m(3)), and distance to high traffic (1,939 m) was associated with a 4.3% (95% confidence interval [CI]: 1.9% to 6.7%), 1.7% (95% CI: -0.7% to 4.1%), and 1.2% (95% CI: -0.2% to 2.6%) increase in CIMT, respectively. Conclusions Our study shows a clear association of long-term exposure to PM2.5 with atherosclerosis. This finding strengthens the hypothesized role of PM2.5 as a risk factor for atherogenesis. (J Am Coll Cardiol 2010;56:1803-8) (C) 2010 by the American College of Cardiology Foundation
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