期刊
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
卷 54, 期 23, 页码 2167-2173出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2009.07.042
关键词
acute myocardial infarction; sudden cardiac death; microemboli; microvascular obstruction
Objectives This study examined myocardial microvascular emboli and obstruction, and related these to plaque in the epicardial coronary arteries supplying the affected microvessels. Background Epicardial coronary thrombosis often causes microemboli and microvascular obstruction. The consequences of myocardial microvessel obstruction and myocyte necrosis are substantial, yet histopathologic characterization of epicardial coronary artery plaque has been incompletely characterized. This study examined myocardial microvascular emboli, and related these to plaque in the coronary arteries supplying the microvessels. Methods Hearts from sudden coronary death patients underwent examination for coronary artery plaque type and cardiac microemboli. Results Forty-four hearts were available for evaluation. Mean age at death was 51 +/- 15 years. Coronary artery analysis found 26 plaque ruptures and 21 erosions, and a mean of 4.5 microemboli per heart. Microemboli and microvascular obstruction occurred most often from eroded plaques. Microemboli and occluded intramyocardial vessels were most common in the left anterior descending coronary artery, and all vessels contained fibrin and platelets. Mean stenoses of the culprit lesion was 74% in those with emboli and 75% in those without (p = NS). Intramyocardial microemboli were more common in plaque erosion than in rupture. Microvessels <200 mu m were most often those that were occluded. Conclusions Microemboli and microvascular obstruction are common in patients dying of acute coronary thrombosis. Plaque erosion is more likely to cause emboli in vessels <200 mu m. These emboli and microvessel obstruction have a prominent clinical role since myonecrosis is often associated with these findings. (J Am Coll Cardiol 2009;54:2167-73) (C) 2009 by the American College of Cardiology Foundation
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