From Mice to Men Commonalities in Physiology for Stem Cell-Based Cardiac Repair

Current treatments for acute myocardial infarction (AMI) involving successful restoration of blood flow into the infarct-related artery either by percutaneous methods or by fibrinolytic therapy have shown to be of benefit in reduction of short-term mortality. While the advantages of these reperfusion strategies are well established, they do not address the loss of myocardium and adverse remodeling that occurs.