期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 140, 期 36, 页码 11184-11188出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.8b06835
关键词
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资金
- National Research Foundation of Korea (NRF) - Korean government (MSIP) [NRF-2016R1A2B3007119, 2016R1A4A1011451]
Chiral Lewis acid catalyzed asymmetric formation of cyclobutanones from alpha-silyloxyacroleins and alpha-alkyl or alpha-aryl diazoesters has been developed. In the presence of a chiral oxazaborolidinium ion catalyst, various alpha-silyloxycyclobutanones possessing a chiral, beta-quaternary center were synthesized in high yield (up to 91%) with excellent enantio- and diastereoselectivity (up to 98% ee and up to >20:1 dr) through tandem cyclopropanation/semipinacol rearrangement. The synthetic potential of this method was illustrated by conversion of the product to various cyclic compounds such as gamma-lactone, cyclobutanol, and cyclopentanone.
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