期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 136, 期 4, 页码 1230-1233出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja4114825
关键词
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资金
- National Basic Research Program of China (973 Program) [2012CB821600]
- National Natural Science Foundation of China [21172242, 21332010]
- SIOC
A first example of Pd-catalyzed gem-difluoroallylation of organoborons using 3-bromo-3,3-difluoropropene (BDFP) in high efficiency with high alpha/gamma-substitution regioselectivity has been developed. The reaction can also be extended to substituted BDFPs and has advantages of low catalyst loading (0.8 to 0.01 mol %), broad substrate scope, and excellent functional group compatibility, thus providing a facile route for practical application in drug discovery and development.
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