期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 136, 期 12, 页码 4551-4556出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja411006a
关键词
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资金
- New York State Stem Cell Science (NYSTEM) [C026715]
- US National Institute of Health [NIH R01CA097061, R01GM085081, R01 CA161061, HD18655, NS066019, DK34275]
- Whitehall Foundation
- William Randolph Hearst Foundation
- Alzheimer's Drug Discovery Foundation
- Baby Alex Foundation
- National Cancer Institute [1K99CA166517-01]
- NSF [CHE 0840451, CHE-06196]
- NIH [ISI0RR025431-01A1]
Ferrostatin-1 (Fer-1) inhibits ferroptosis, a form of regulated, oxidative, nonapoptotic cell death. We found that Fer-1 inhibited cell death in cellular models of Huntington's disease (HD), periventricular leukomalacia (PVL), and kidney dysfunction; Fer-1 inhibited lipid peroxidation, but not mitochondrial reactive oxygen species formation or lysosomal membrane permeability. We developed a mechanistic model to explain the activity of Fer-1, which guided the development of ferrostatins with improved properties. These studies suggest numerous therapeutic uses for ferrostatins, and that lipid peroxidation mediates diverse disease phenotypes.
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