期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 136, 期 5, 页码 1766-1769出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja412023b
关键词
-
资金
- National Basic Research Program of China [973-2011CB808700]
- National Nature Science Foundation of China [21225210, 21202185, 21121062]
- Science and Technology Commission of the Shanghai Municipality [11JC1415000]
- CAS/SAFEA International Partnership Program for Creative Research Teams
A palladium-catalyzed intramolecular aminohydroxylation of alkenes was developed, in which H2O2 was applied as the sole oxidant. A variety of related alkyl alcohols could be successfully obtained with good yields and excellent diastereoselectivities, which directly derived from oxidation cleavage of alkyl C-Pd bond by H2O2. Facile transformation of these products provided a powerful tool toward the synthesis of 2-amino-1,3-diols and 3-ol amino acids. Preliminary mechanistic studies revealed that major nucleophilic attack of water (S(N)2 type) at high-valent Pd center contributes to the final C-O(H) bond formation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据