4.8 Article

Cu(II)-Mediated Ortho C-H Alkynylation of (Hetero)Arenes with Terminal Alkynes

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 136, 期 33, 页码 11590-11593

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AMER CHEMICAL SOC
DOI: 10.1021/ja507704b

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资金

  1. Shanghai Institute of Organic Chemistry
  2. Chinese Academy of Sciences
  3. CAS/SAFEA
  4. Recruitment Program of Global Experts
  5. Scripps Research Institute
  6. NSF under the CCI Center for Selective C-H Functionalization [CHE-1205646]

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Cu(II)-promoted ortho alkynylation of arenes and heteroarenes with terminal alkynes has been developed to prepare aryl alkynes. A variety of arenes and terminal alkynes bearing different substituents are compatible with this reaction, thus providing an alternative disconnection to Sonogashira coupling.

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