期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 136, 期 40, 页码 14019-14022出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja508757g
关键词
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资金
- National Institutes of Health [NIH R01-GM096403]
We report a peptide-based catalyst that can strongly influence the regio- and enantioselectivity of the Baeyer-Villiger (BV) oxidation of cyclic ketones bearing amide, urea, or sulfonamide functional groups. Both types of selectivity are thought to arise from a catalyst-substrate hydrogen-bonding interaction. Furthermore, in selected cases, the reactions exhibit the hallmarks of parallel kinetic resolution. The capacity to use catalysis to select between BV products during an asymmetric process may have broad utility for both the synthesis and diversification of complex molecules, including natural products.
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