期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 136, 期 8, 页码 3285-3292出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja412996f
关键词
-
资金
- National Science Foundation [CHE-0848224]
- Israel US Binational Science Foundation
A selective peptide-catalyzed addition of allenic esters to N-acylimines is reported. Tetrasubstituted allenes were achieved with up to 42:1 diastereomeric ratio and 94:6 enantiomeric ratio (up to 99:1 er after recrystallization of the major diastereomer). An exploration of the role of individual amino acids within the peptide was undertaken. The scope of the reaction was explored and revealed heightened reactivity with thioester-containing allenes. A mechanistic framework that may account for the observed reactivity is also described.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据