期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 136, 期 31, 页码 10834-10837出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja503322e
关键词
-
资金
- NIH/NIGMS [2R01 GM 076153B]
The synthesis of chroman, isochroman, and pyran motifs has been accomplished via a combination of Pd(II)/bis-sulfoxide C-H activation and Lewis acid co-catalysis. A wide range of alcohols are found to be competent nucleophiles for the transformation under uniform conditions (catalyst, solvent, temperature). Mechanistic studies suggest that the reaction proceeds via initial C H activation followed by a novel inner-sphere functionalization pathway. Consistent with this, the reaction shows reactivity trends orthogonal to those of traditional Pd(0)-catalyzed allylic substitutions.
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