期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 136, 期 18, 页码 6534-6537出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja500029w
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资金
- NIH [GM-59471]
Catalytic enantiotopic-group-selective cross-couplings of achiral geminal bis(pinacolboronates) provide a route for the construction of nonracemic chiral organoboronates. In the presence of a chiral monodentate taddol-derived phosphoramidite ligand, these reactions occur with high levels of asymmetric induction. Mechanistic experiments with chiral B-10-enriched geminal bis(boronates) suggest that the reaction occurs by a stereochemistry-determining transmetalation that occurs with inversion of configuration at carbon.
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