期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 136, 期 17, 页码 6203-6206出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja501664f
关键词
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资金
- National Natural Science Foundation of China [21204056, 81171479]
- Natural Science Foundation of Jiangsu Province [BK2012173, BK2011291]
- China Scholarship Council [201308320113]
- China Postdoctoral Science Foundation [2012M520060, 2013T60555]
- Jiangsu Provincial Special Program of Medical Science [BL2012004]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1308363] Funding Source: National Science Foundation
In this work, dynamic introduction of bioactive RGD peptide on a matrix was successfully demonstrated via reversible multicovalent interactions within PBA/cis-diol polymeric complexes. These reversible, stable multiple interaction sites, in addition to a long accessible polymeric linker, enabled reversible control of cell adhesion by specific biomolecular exchange (e.g., glucose or fructose). This biomolecule-triggered, non-invasive strategy shows great promise for use in real-time biological research and mimics natural biomolecular feedback systems, thus having potential application in medical diagnoses and regenerative medicine.
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