期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 136, 期 5, 页码 1789-1792出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja413131m
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资金
- Indiana University Purdue University Indianapolis
- NSF-MRI [CHE-0619254]
The direct alkylation of unactivated sp(3) C-H bonds of aliphatic amides was achieved via nickel catalysis with the assist of a bidentate directing group. The reaction favors the C-H bonds of methyl groups over the methylene C-H bonds and tolerates various functional groups. Moreover, this reaction shows a predominant preference for sp(3) C-H bonds of methyl groups via a five-membered ring intermediate over the sp(2) C-H bonds of arenes in the cyclometalation step.
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