期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 136, 期 25, 页码 9225-9234出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja504213m
关键词
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资金
- ERC
- Marie Curie Fellowship
- Engineering and Physical Sciences Research Council [EP/L002957/1] Funding Source: researchfish
- EPSRC [EP/L002957/1] Funding Source: UKRI
The design and construction of higher-order structure and function in proteinosome microcompartments enclosed by a cross-linked membrane of amphiphilic bovine serum albumin/poly(N-isopropylacrylamide) (BSA-NH2/PNIPAAm) nanoconjugates is described. Three structure/function relationships are investigated: (i) differential chemical cross-linking for the control of membrane disassembly and regulated release of encapsulated genetic polymers; (ii) enzyme-mediated hydrogel structuring of the internal microenvironment to increase mechanical robustness and generate a molecularly crowded reaction environment; and (iii) self-production of a membrane-enclosing outer hydrogel wall for generating protease-resistant forms of the protein-polymer protocells. Our results highlight the potential of integrating aspects of supramolecular and polymer chemistry into the design and construction of novel bioinspired microcompartments as a step toward small-scale materials systems based on synthetic cellularity.
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