期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 136, 期 4, 页码 1162-1165出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja408513m
关键词
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资金
- AFOSR via PECASE [FA9550-11-1-0105]
- AFOSR [FA9550-12-1-0414]
- AFOSR via ARO [W911NF-11-1-0264]
- NIH [NIBIB R01EB011633]
- NIH New Innovator award [DP2OD008724]
- UCSD Cancer Researchers in Nanotechnology
- Department of Energy's Office of Biological and Environmental Research
- U.S. Department of Energy [DE-AC05-76RL01830]
- NIH
In this paper we present in situ transmission electron microscopy of synthetic polymeric nanoparticles with emphasis on capturing motion in a solvated, aqueous state. The nanoparticles studied were obtained from the direct polymerization of a Pt(II)-containing monomer. The resulting structures provided sufficient contrast for facile imaging in situ. We contend that this technique will quickly become essential in the characterization of analogous systems, especially where dynamics are of interest in the solvated state. We describe the preparation of the synthetic micellar nanoparticles together with their characterization and motion in liquid water with comparison to conventional electron microscopy analyses.
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