期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 136, 期 38, 页码 13198-13201出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja508441t
关键词
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资金
- JSPS.KAKENHI [23350039]
- Program for Leading Graduate Schools IGER program in Green Natural Sciences, MEXT, Japan
- Grants-in-Aid for Scientific Research [23350039] Funding Source: KAKEN
We developed 1,3-dipolar cycloadditions of azomethine imines with propioloylpyrazoles catalyzed by a chiral copper(II) complex of 3-(2-naphthyl)-L-alanine amide. The asymmetric environment created by intramolecular pi-cation interaction and the N-alkyl group of the chiral ligand gives the corresponding adducts in high yields with excellent enantioselectivity. This is the first successful method for the catalytic enantioselective 1,3-dipolar cycloaddition of azomethine imines with internal alkyne derivatives to give fully substituted pyrazolines.
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