期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 136, 期 12, 页码 4496-4499出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja501093m
关键词
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资金
- Ministry of Education, Culture, Sports, Science & Technology, Japan [2105]
- JSPS
- Grants-in-Aid for Scientific Research [13J05567, 21106001, 25620081, 25410200, 21106002] Funding Source: KAKEN
A method for the C-N coupling of imidazoles based on electrooxidative C-H functionalization of aromatic and benzylic compounds has been developed. The key to the success is the formation of protected imidazolium ions as initial products, avoiding overoxidation. Deprotection under nonoxidative conditions affords N-substituted imidazoles. Various functional groups are compatible with the present transformation. To demonstrate the power of the method, a P450 17 inhibiter and an antifungal agent having N-substituted imidazole structures were synthesized.
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