期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 136, 期 50, 页码 17359-17361出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja508648s
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资金
- JSPS [21000005, 09J09272]
- Naito Foundation
- Grants-in-Aid for Scientific Research [21000005, 09J09272] Funding Source: KAKEN
Here we report in vitro ribosomal synthesis of a natural product-like macrocyclic peptide, inspired by the structure of amphotericin B (AmB), an amphiphilic and membrane-interacting antifungal natural product. This AmB-inspired macrocyclic peptide (AmP), one side of which is composed of hydrophobic terpene, and the other side comprises a peptidic chain, was synthesized utilizing flexizyme-assisted in vitro translation via an unusual but successful initiation with a d-cysteine derivative. The established method for the synthesis of AmPs is applicable to the generation of a diverse AmP library coupled with an in vitro display format, with the potential to lead to the discovery of artificial bioactive amphiphilic macrocycles.
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