期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 136, 期 48, 页码 16708-16711出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja5080773
关键词
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资金
- Italian MIUR
- Italian Association for Cancer Research (A.I.R.C.) [11567, 11947]
- ligue contre le Cancer
- Umberto Veronesi Foundaion
- A.I.R.C.
The shelterin protein TRF2 has come to the limelight for its role in telomere maintenance and tumorigenesis. Herein, the application of rational design and synthesis allowed identifying the first TRF2(TRFH) binder able to elicit a marked DNA damage response in cancer cells. This work paves the way for the unprecedented employment of a chemical tool to finely tune specific mechanisms underlying telomere maintenance.
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