期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 136, 期 40, 页码 14314-14319出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja5093612
关键词
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资金
- state of Mecklenburg-Vorpommern
- BMBF
A straightforward process for the N-alkylation of amines has been developed applying readily available carboxylic acids and silanes as the hydride source. Complementary to known reductive aminations, effective C-N bond construction proceeds under mild conditions and allows obtaining a broad range of alkylated secondary and tertiary amines, including fluoroalkyl-substituted anilines as well as the bioactive compound Cinacalcet HCl.
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