4.8 Article

Concise Enantiospecific Total Synthesis of Tubingensin A

期刊

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 136, 期 8, 页码 3036-3039

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AMER CHEMICAL SOC
DOI: 10.1021/ja501142e

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资金

  1. NCRR NIH HHS [S10RR025631, S10 RR025631] Funding Source: Medline
  2. NIGMS NIH HHS [R01 GM090007] Funding Source: Medline
  3. Direct For Mathematical & Physical Scien [1048804] Funding Source: National Science Foundation
  4. Division Of Chemistry [1048804] Funding Source: National Science Foundation

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We report the enantiospecific total synthesis of (+)-tubingensin A. Our synthesis features an aryne cyclization to efficiently introduce the vicinal quaternary stereocenters of the natural product and proceeds in only nine steps (longest linear sequence) from known compounds.

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