期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 136, 期 36, 页码 12596-12599出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja507506c
关键词
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资金
- U.S. DOE [DE-FG01-98ER14888]
- EPSRC [EP/K003674/1]
- U.S. Department of Education
- EPSRC
- BBSRC
- University of Warwick via Birmingham Science City Advanced Materials Projects - Advantage West Midlands
- European Regional Development Fund
- EPSRC [EP/K003674/1, EP/F017901/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/F017901/1, EP/K003674/1] Funding Source: researchfish
Supramolecular hydrogels derived from natural products have promising applications in diagnostics, drug delivery, and tissue engineering. We studied the formation of a long-lived hydrogel made by mixing guanosine (G, 1) with 0.5 equiv of KB(OH)(4). This ratio of borate anion to ligand is crucial for gelation as it links two molecules of 1, which facilitates cation-templated assembly of G4 center dot K+ quartets. The guanosineborate (GB) hydrogel, which was characterized by cryogenic transmission electron microscopy and circular dichroism and 11B magic-angle-spinning NMR spectroscopy, is stable in water that contains physiologically relevant concentrations of K+. Furthermore, non-covalent interactions, such as electrostatics, ?-stacking, and hydrogen bonding, enable the incorporation of a cationic dye and nucleosides into the GB hydrogel.
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